Sepsis
Conditions
Interventions
Group 1:Antibiotics directed by nanopore sequencing
Group 2:Empirical use of antibiotics
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Suspected sepsis patients, meet any of the following (1) plus (2)-(4): (1) Infection or suspected infection; (2) qSOFA>=2; (3) SOFA=1 ; (4) NEWS score 4-6 points. 2. Patients with sepsis: meet the clinical diagnostic criteria of sepsis or septic shock according to the 3rd edition of the International Consensus Definition of Sepsis and Septic Shock (Sepsis-3).
Exclusion criteria
Exclusion criteria: 1. Aged <18 years; 2. Suffering from autoimmune diseases, acquired immune deficiency syndrome, agranulocytosis, malignant tumors or other serious chronic diseases (heart failure, liver failure, end-stage renal disease, etc.); 3. Are receiving glucocorticoid therapy; 4. Pregnancy; 5. Refuse to join the group or give up active treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day composite endpoint of septic shock and death; | — |
Secondary
| Measure | Time frame |
|---|---|
| Detection rate of pathogen;Duration of antibiotic treatment;Type and duration of respiratory support;Duration of vasoactive drugs;Duration of continuous renal replacement therapy (CRRT);Systemic infection-related organ failure score;Improved early warning score (MEWS); | — |
Countries
China
Contacts
Public ContactChen Yuguo
Qilu Hospital of Shandong University
Outcome results
None listed