Idiopathic membranous nephropathy
Conditions
Interventions
Sponsors
Department of Nephrology, Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Idiopathic membranous nephropathy was confirmed by renal biopsy pathology or high titer anti-PLA2R antibody; 2.Aged 18 to 65 years; 3.Male and female patients of childbearing age have negative pregnancy test results and agree to take contraceptive measures; 4.After treatment with standard dose of ACEI or ARB for more than 3 months, the quantitative results of 24-hour proteinuria were still between 1.0 and 6.0 g; 5.EGFR >60 ml/min/1.73 m^2; 6.Agrees to voluntarily participate in the study and signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Glucocorticoids or other immunosuppressants have been used in the past 6 months; 2.Clinical evidence of secondary membranous nephropathy (tumors, drugs, other autoimmune diseases such as systemic lupus erythematosus, etc.); 3.Complicated with chronic liver disease, myocardial infarction, stroke, uncontrollable hypertension and diabetes, malignant tumor; 4.Known allergy to tripterygium wilfordii polyglycosides or contraindications for use; 5.Female patients who are pregnant (or intend to be pregnant within half a year), breastfeeding or unwilling to take contraceptive measures; 6.Life expectancy is less than 6 months; 7.Are currently participating or have participated in other clinical trials within 3 months; 8.Refuse to sign an informed consent form or are unable or unwilling to comply with a research protocol approved by the researcher; 9.The researchers believe that it is not suitable to participate in other situations of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absolute decrease in urinary protein quantification relative to baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Absolute decrease in the ratio of urinary albumin to creatinine in morning urine relative to baseline;Percentage of patients who met criteria for clinical efficacy;Compound renal endpoint events; | — |
Countries
China
Contacts
Public ContactFeng Yunlin
Department of Nephrology, Sichuan Provincial People's Hospital
Outcome results
None listed