Corneal endotheliopathy
Conditions
Interventions
Experimental group:Injective corneal endothelial transplantation
Control group:Drag corneal endothelial transplantation
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Because of Fuchs endothelial dystrophy, intraocular lens bullous keratopathy, aphakic bullous keratopathy, endothelial failure after penetrating keratoplasty and other causes of bullous keratopathy, patients need corneal endothelial transplantation; 2.Age >= 18 years old, regardless of gender; 3.All patients had informed consent.
Exclusion criteria
Exclusion criteria: 1.Preoperative intraocular pressure control was poor (IOP > 21mmhg in the latest month); 2.Silicone oil eye; 3.Uveitis occurred repeatedly; 4.Viral keratodermatitis; 5.Iris septal defect of water eye, congenital ocular dysplasia, and all other conditions that seriously affect surgical procedures; 6.Eye infection, intraocular inflammation subsided less than 1 month; 7.Internal eye surgery was performed within 3 months before screening or during the study period; 8.Pregnant and lactating women or women of childbearing age do not take effective contraceptive measures; 9.Preoperative fasting blood glucose > 9.0mmol/l, severe cardiovascular disease history (uncontrollable hypertension, unstable coronary heart disease or myocardial infarction or severe arrhythmia) can not tolerate surgery; 10.The researcher judged that it was not suitable to participate in other situations of the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal endothelial cell density;Corneal endothelial cell loss rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual function;Intraocular pressure;Corneal thickness;Time of operation;Intraoperative and postoperative complications;Graft survival rate; | — |
Countries
China
Contacts
Public ContactChen Wei
The School of Ophthalmology and Optometry, Wenzhou Medical University
Outcome results
None listed