sepsis
Conditions
Interventions
Hyperinflammation + immunosuppression group:Methylprednisolone 40 mg bid + one a-thymosin bid
Hyperinflammation + no immunosuppression group:Methylprednisolone 40 mg bid
Hypoinflammation + immunosuppression group:one a-thymosin bid
Hypoinflammation + immunosuppression group:Regular treatment
Control group:Regular treatment
Sponsors
Renji Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Meet the sepsis 3.0 diagnostic criteria; 2.Aged >=18 years; 3.Sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Aged >= 80 years; 2.HIV infection; 3.Receiving anti-tumor chemotherapy in the last three months; 4.Being receiving immunosuppressive treatment due to organ transplantation and immune diseases; 5.Allogeneic bone marrow suppression or stem cell transplantation; 6.Use hormone therapy for the past three months (0.5mg/kg prednisone treatment or equivalent other hormones for more than 30 days); 7.Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day patient mortality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Death rate in intensive care unit;Hospital fatality rate;Functional indicators of all organs; | — |
Countries
China
Contacts
Public ContactGao Yuan
Renji Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed