Schizophrenia
Conditions
Interventions
Schizophrenia group:Parliperidone
Sponsors
Institute of Mental Health, the Sixth Hospital of Peking University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Each patient should be diagnosed as schizophrenia according to the DSM-IV-TR criteria; 2.Aged 18 to 45 years, han nationality, no gender limitation; 3.Biological parents are Chinese Han descents; 4.Patients with schizophrenia who are in the acute stage of the first episode without medication or chronic course of disease; 5.The total score of the Positive and Negative Symptom Scale (PANSS) >=60 points (1-7 scale), among the 7 positive symptom items, the score >=4 must be >=3; 6.Obtain the written informed consent of the patient, or the written informed consent of the legal guardian if the patient is incapacitated during the onset.
Exclusion criteria
Exclusion criteria: 1.Pregnant or breast-feeding women or those planning to become pregnant; 2.Patients with contraindications to paliperidone; 3.Patients with severe or unstable physical diseases; 4. Having the following cardiac conditions: prolonged QTc interval (QTc>=450 ms in men or 470 ms in women); Decompensated congestive heart failure; Complete left bundle branch block.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive And Negative Syndrome Scale, PANSS;Gene data; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical global impression, CGI; | — |
Countries
China
Contacts
Public ContactYue Weihua
Institute of Mental Health, the Sixth Hospital of Peking University
Outcome results
None listed