The effect of minimal-dose S-ketamine on opioids consumption in postoperative analgesia for patients undergoing minimally invasive radical resection of esophageal cancer

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100048311

Enrollment

Unknown

Registered

2021-07-05

Start date

2022-06-01

Completion date

Unknown

Last updated

2025-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal cancer

Interventions

Experimental group:S-ketamine 0.015mg/kg/h was pumped immediately after the operation for 48h

Control group:0.9% normal saline was pumped continuously for 48h

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Aged 18-80 years; 2.Patients preparing for radical resection of esophageal cancer. 3.ASA I-III.

Exclusion criteria

Exclusion criteria: 1. Allergy to S-ketamine or oxycodone; 2. Unstable ischemic cardiac disease; 3. Increased intracranial or intraocular pressure; 4. Untreated or poorly treated hyperthyroidism; 5. Psychiatric disease; 6. Severe hepatic dysfunction (Child–Pugh grade C); 7. Renal failure (requiring renal replacement therapy); 8. Severe respiratory dysfunction (respiratory failure type I or type II ); 9. Previous long-term use of analgesics; 10. Patients with previous basic pain (chronic pain); 11. Conversion to thoracotomy; 12. Transfer to intensive care unit (ICU); 13. Unwillingness or inability to use a patient-controlled analgesia (PCA) device; 14. Cognitive impairment or inability to communicate.

Design outcomes

Primary

Measure	Time frame
Cumulative opioid consumption in the first 48 hours postoperatively. ;	—

Secondary

Measure	Time frame
Numerical rating scale (NRS) pain scores at rest and when coughing;Pain scores and area under curve (AUC) in different postoperative time periods ;Functional activity score (FAS);Cumulative opioid consumption in different postoperative time periods;Incidence of postoperative nausea and vomiting (PONV);Level of sedation (LOS) score;Time to first postoperative flatulence;Postoperative delirium;Activities of daily living (Barthel Index,BI) score;Pulmonary and other complications;Duration of chest tube placement;Length of postoperative hospital stay;Satisfaction levels of medical staff and patients.;	—

Measure

Time frame

Numerical rating scale (NRS) pain scores at rest and when coughing;Pain scores and area under curve (AUC) in different postoperative time periods ;Functional activity score (FAS);Cumulative opioid consumption in different postoperative time periods;Incidence of postoperative nausea and vomiting (PONV);Level of sedation (LOS) score;Time to first postoperative flatulence;Postoperative delirium;Activities of daily living (Barthel Index,BI) score;Pulmonary and other complications;Duration of chest tube placement;Length of postoperative hospital stay;Satisfaction levels of medical staff and patients.;

—

Countries

China

Contacts

Public ContactXie Jue

Zhongda Hospital, Southeast University

very_wang@126.com+86 180 1389 8998

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026