diabetic kidney disease
Conditions
Interventions
Case series:Nil
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria for diabetic normal proteinuria group: (1)Meet the diabetic diagnosis criteria; (2)Aged 18 to 75 years; (3)Urinary albumin-creatinine ratio (60 ml / (min 1.73m^2); (4)Informed consent. 2.DKD III group inclusion criteria: (1)Meet the diagnostic criteria of diabetes mellitus; (2)Aged 18 to 75 years; (3)Urinary albumin-creatinine ratio twice 30 mg / g-300 mg / g, glomerular filtration rate (> 60 ml / (min. 1.73 m^2); (4)With diabetic retinopathy or type 1 diabetes mellitus for more than 10 years; type 2 diabetes mellitus for 5 years; (5)Informed consent. 3.DKD IV group inclusion criteria: (1)Meet the diabetes diagnostic criteria; (2)Aged 18 to 75 years; (3)Urinary albumin creatinine ratio > 300 mg/g twice three times; glomerular filtration rate (> 60 ml / (min. 1.73 m^2); (4)Diabetic retinopathy or type 1 diabetes more than 10 years, type 2 diabetes more than 5 years ; (5)Informed consent. 4.Nephropathy incompatible with diabetes group inclusion criteria: (1)Does not meet the diagnostic criteria of diabetes; (2)Aged 18 to 75 years without diabetes; (3)Clearly diagnosed as a variety of kidney diseases and renal vascular diseases; (4)Informed consent.
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria for diabetic normal proteinuria group, DKD III group and DKD IV group: (1)Pregnant or lactating patients; (2)Psychiatric patients who can not understand the nature, scope and possible results of the study or can not comply with medical advice; (3)Diabetic ketoacidosis, hyperglycemic hyperosmotic syndrome, diabetic lactic acidosis and other acute complications A patient with a disease; (4)Significant abnormal blood and urine patterns, systemic or urinary tract infections, urinary calculi, complicated with other kidney diseases and renal vascular diseases, severe cardio-hepatic insufficiency, connective tissue disease, malignant tumor, stress state, cardiac infarction, angina pectoris, cerebral infarction occurred within the past 6 months; (5)Nephrotoxic drug-induced diseases were used within 1 month; (6)Sudden edema and normal renal function; (7)Refractory hypertension. 2. Exclusion criteria for nephropathy incompatible with diabetes mellitus: (1)Pregnant or lactating; (2)Psychiatric patients who can not understand the nature, scope and possible results of the study or can not comply with medical advice; (3)Severe cardio-hepatic insufficiency, connective tissue disease, malignant tumor, stress state, cardiac infarction, angina pectoris, cerebral infarction within the past six months; (4)A history of nephrotoxic drugs was used within a month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine proteome; | — |
Countries
China
Contacts
Public ContactFan Guanjie
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed