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Effect of tranexamic acid on blood loss in patients undergoing endoscopic resection of skull base chordoma

A randomized controlled clinical study of tranexamic acid for reducing intraoperative blood loss in adult patients with skull base chordoma resection

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100048299
Enrollment
Unknown
Registered
2021-07-05
Start date
2021-07-01
Completion date
Unknown
Last updated
2022-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skull base chordoma

Interventions

Experimental group:Intravenous tranexamic acid
Control group:Normal saline

Sponsors

Beijing Tiantan Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective endoscopic resection of skull base chordoma; 2. Aged 18-65 years; 3. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Take antiplatelet drugs (aspirin, clopidogrel, warfarin, etc. within 5 days before surgery); 2. Hepatic and renal insufficiency (renal insufficiency refers to creatinine > 1.6 mg/dl in male patients, creatinine > 1.4 mg/dl in female patients, or patients requiring dialysis treatment; hepatic insufficiency refers to Child Pugh grades B and C ); 3. Anemia (hemoglobin 1.5, platelet count < 100 x 10^9/L, fibrinogen < 1 g/L); 5. The presence of arterial and venous thrombosis; 6. Past history of old cerebral infarction; 7. History of adverse reactions to tranexamic acid.

Design outcomes

Primary

MeasureTime frame
Perioperative blood loss;—

Secondary

MeasureTime frame
Transfusion blood;Bleeding on the first day after surgery;Embolism events;Epilepsy consult;30 days all-cause mortality;Coagulation;Length of hospital stay;Length of ICU stay;—

Countries

China

Contacts

Public ContactHan Ruquan

Beijing Tiantan Hospital, Capital Medical University

ruquanhan@gmail.com+86 13701285393

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026