Hypertensive disorders of pregnancy
Conditions
Interventions
case series:None
Sponsors
Women's Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Evaluation of the effect of aspirin in preventing preeclampsia and serious pregnancy complications: (1) 11-13+6 gestational weeks; (2) Aged >=18 years; (3) Singleton pregnancy, the fetus survives; (4) Agree to participate and sign the informed consent form. 2. Establishment of a risk prediction model for severe pregnancy complications in hypertensive disorders of pregnancy: (1) 20-36+6 gestational weeks; (2) Diagnosed with >= 1 of the following diseases: gestational hypertension, preeclampsia, pregnancy complicated with chronic hypertension, chronic hypertension with preeclampsia; (3) Aged >18 years; (4) Singleton pregnancy, fetal survival; (5) Agree to participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Evaluation of the effect of aspirin in preventing preeclampsia and serious pregnancy complications: (1) Serious fetal malformation/abnormality; (2) Routine use of aspirin before enrollment; (3) Aspirin contraindications such as salicylic acid allergy, peptic ulcer disease, bleeding history, liver cirrhosis, renal failure, platelet count <50x10^9/L, hematocrit <10%, hemophilia, congenital platelets disease, fibrinogen deficiency or deficiency, use of antiplatelet drugs other than aspirin, use of anti-inflammatory drugs, or use of warfarin; (4) Those who have been diagnosed with pregnancy-induced hypertension; (5) Severe mental disorders, unable to express their wishes; (6) There are obvious other abnormal signs, laboratory examinations and other clinical diseases, and according to the judgment of the researcher, they are not suitable to participate in the researcher; (7) According to the investigator's judgment, it is impossible to observe and follow-up to obtain delivery information. 2. Establishment of a risk prediction model for severe pregnancy complications in hypertensive disorders of pregnancy: (1) Serious fetal malformation/abnormality; (2) Severe mental disorders, unable to express their wishes; (3) There are obvious other abnormal signs, laboratory examinations and other clinical diseases, and according to the judgment of the investigator, they are not suitable to participate in the researcher; (4) According to the investigator's judgment, it is impossible to observe and follow-up to obtain delivery information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arachidonic acid inhibition rate;Placental growth factor;Mean arterial pressure;Uterine arterial pulse index; | — |
Secondary
| Measure | Time frame |
|---|---|
| S/D ratio of umbilical artery;Umbilical artery pulsatility index;Pregnancy associated plasma protein-A;Armor embryo protein;Human Chorionic Gonadotropin;Progesterone;Free estriol; | — |
Countries
China
Contacts
Public ContactLi Baohua
Women's Hospital, School of Medicine, Zhejiang University
Outcome results
None listed