Knee osteoarthritis
Conditions
Interventions
Experimental group:Flurbiprofen gel patch (gel patch) + celecoxib (oral capsule)
Control group:Placebo (gel patch) + celecoxib (oral capsule)
Sponsors
Shenzhen Second People's Hospital/The First Affiliated Hospital of Shenzhen University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 55-80 years; 2. Has been diagnosed with knee osteoarthritis, X-ray examination diagnosed as knee osteoarthritis grade III and below (Kellgren-Lawrence classification), and has symptoms of osteoarthritis; 3. Live in the community before joining the group; 4. Able to walk independently with or without assistive equipment.
Exclusion criteria
Exclusion criteria: 1. Allergic to flurbiprofen or celecoxib; 2. Have received knee or hip surgery within 3 months before enrollment, causing pain or affecting joint function; 3. Systemic or intra-articular use of corticosteroids within 2 months after enrollment; 4. Intra-articular injection of steroids or hyaluronic acid within 4 weeks after enrollment; 5. Serious skin disease, unable to use flurbiprofen gel patch; 6. Failure to arrive at the designated place (such as a hospital) on time for follow-up or examination. 7. Consciousness is not clear and cannot answer questions correctly.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total dosage of celecoxib;Swelling of the knee joint;Laboratory test results;Complication rate; | — |
Countries
China
Contacts
Public ContactYou Wei
Shenzhen Second People's Hospital/The First Affiliated Hospital of Shenzhen University
Outcome results
None listed