The safety and efficacy of remimazolam as a potential anesthesia induction agent during endotracheal intubation in spontaneous breathing patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100048242

Enrollment

Unknown

Registered

2021-07-05

Start date

2021-08-01

Completion date

Unknown

Last updated

2022-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Control group:Sevoflurane anesthesia induction

Experimental group:Remazolam anesthesia induction

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18-65 years (including the cut-off value) receiving general anesthesia with endotracheal intubation; 2. The patients participated voluntarily and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Weight less than 40 kg or BMI> 30kg/m^2; 2. Suffering from the following diseases: central nervous system disease; hypertension grade 2 and above, NYHA grade II and above heart disease; 3. Preoperatively predicted difficult airway, after tracheotomy, upper airway obstruction (airway foreign body, snoring, etc.), abnormal nasopharyngeal cavity (sinusitis, turbinate hypertrophy, nasal septum deviation, nasopharyngeal cancer, etc.) and others diseases affecting normal ventilation; 4. Lung diseases affecting normal oxygenation (pneumonia, COPD, bronchiectasis, emphysema, asthma, silicosis, pneumoconiosis, post lobectomy, etc.); 5. Digestive system diseases such as intragastric hypertension, intestinal obstruction, perforation, and necrosis.

Design outcomes

Primary

Measure	Time frame
The success rate of intubation induced by anesthesia with spontaneous breathing;	—

Secondary

Measure	Time frame
Anesthesia sedation time;Anesthesia induction time;	—

Countries

China

Contacts

Public ContactChen Yuqing

Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University

chenyq97@mail.sysu.edu.cn+86 18144889570

Outcome results