None listed
Conditions
Interventions
Control group:propofol
Sponsors
Wuming Hospital Affiliated to Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years, gender is not limited; 2. American Anesthesiologist Classification (ASA) I-II; 3. Gastrointestinal tumor patients who require tracheal intubation and general anesthesia for elective surgery; 4. Vital signs: respiratory rate >=10 and =95% when breathing air; systolic blood pressure (SBP) >=90mmHg and =60mmHg and =55 and =18 and <=30kg/m^2; 5. Be able to understand the research process and methods, and voluntarily participate in this research.
Exclusion criteria
Exclusion criteria: 1. Those with contraindications to general anesthesia or those who have had a history of anesthesia accident in the past; 2. Known or suspected allergies or contraindications to propofol injection, cyclopofol injection excipients, benzodiazepines, opioids, muscle relaxants, etc.; 3. Combined with craniocerebral loss, intracranial hypertension, stroke, unstable angina, myocardial infarction; 4. Respiratory insufficiency, obstructive pulmonary disease, having a difficult airway, or being judged to have difficulty in endotracheal intubation (modified Markov score grade III or IV) 5. Uncontrolled diabetes or high blood pressure; 6. Severe liver dysfunction or severe renal insufficiency; 7. History of alcoholism or drug dependence; 8. Abuse or long-term use of narcotic, sedative, and analgesic drugs; 9. Those who have a history of mental illness in the past; 10. Those who have participated in any drug clinical trials within 1 month before screening; 11. Pregnant and lactating patients; fertile patients who are unwilling to use contraception throughout the trial period; subjects (including male subjects) who have a pregnancy plan within 1 month after the trial; 12. Patients who are considered by the investigator to have any other factors that are not suitable for participating in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of successful anesthesia induction;Length of disappearance of eyelash reflex;Changes of BIS in EEG;Duration of operation, length of intubation (from the start of intubation to extubation), length of stay in PACU;Study drug and alternative drug use;Satisfaction evaluation of anesthesia induction physicians;Adverse events;Vital signs;Evaluation of injection pain;Intubation response;Incidence of intraoperative awareness; | — |
Countries
China
Contacts
Public ContactChen Xiaoyun
Wuming Hospital Affiliated to Guangxi Medical University
Outcome results
None listed