Clinical study of mixed use of esketamine and propofol to prevent propofol injection pain

Mixed use of esketamine and propofol to prevent propofol injection pain: a prospective, multicenter, double-blind, randomized and controlled clinical study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100048219

Enrollment

Unknown

Registered

2021-07-05

Start date

2021-07-05

Completion date

Unknown

Last updated

2022-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group 1:normal saline

Group 2:0.2mg/ml esketamine

Group 3:0.6mg/ml esketamine

Group 4:1mg/ml esketamine

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Aged 18-60 years, ASA I-II.

Exclusion criteria

Exclusion criteria: 1. Liver and kidney insufficiency; 2. Patients with poor respiratory function and low partial pressure of oxygen; 3. Allergy to the research drug; 4. Patients with severely elevated blood pressure or intracranial pressure; 5. Patients with poorly controlled or untreated hypertension; 6. Pre-eclampsia and eclampsia; 7. Untreated or insufficiently treated patients with hyperthyroidism; 8. Obese and thin patients; 9. Vulnerable groups (infants, pregnant women, elderly patients); 10. Patients taking sedative analgesics.

Design outcomes

Primary

Measure	Time frame
Pain;	—

Secondary

Measure	Time frame
Vital signs;	—

Countries

China

Contacts

Public ContactGuan Xuehai

First Affiliated Hospital of Guangxi Medical University

guan_xh@aliyun.com+86 18587697310

Outcome results