Chronic ITP in children
Conditions
Interventions
experiment group:second-line ascending treatment strategy
Sponsors
Beijing Children Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 14 Years
Inclusion criteria
Inclusion criteria: 1. The ITP diagnosis meets the 2019 ICR diagnostic criteria; 2. Aged 1 to 14 years before starting treatment; 3. Chronic ITP: the course of the disease exceeds 12 months; 4. Severe: the number of platelets is less than 30x10^9/L, the combined bleeding (grade 1-3 bleeding) requires treatment or interferes with life, and the parents or children strongly demand treatment; 5. Ineffective first-line treatment: those who have previously used gamma globulin and/or glucocorticoid treatment ineffective; 6. No contraindications to drug treatment; 7. It can ensure long-term follow-up in the diagnosis and treatment center; 8. Obtain the consent of the patient or/and the guardian and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. There was life-threatening bleeding at the time of enrollment, and the ICR bleeding score scale was level 4; 2. Any significant abnormal coexisting diseases or mental illnesses, affecting the patient's life safety and compliance, affecting informed consent, research participation, follow-up or results Explanation; 3. The child or guardian cannot be followed up, and the compliance is poor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life improvement rate;Expenses during treatment; | — |
Countries
China
Contacts
Public ContactWu Runhui
Beijing Children Hospital, Capital Medical University
Outcome results
None listed