Offspring Neurocognitive development delay
Conditions
Interventions
Case series:None
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 34 Years
Inclusion criteria
Inclusion criteria: 1. Singleton, full-term and cephalic primipara who have regular obstetric examinations in the research unit during the study period and plan to deliver vaginally in the research unit; 2. Aged 18 to 35 years.
Exclusion criteria
Exclusion criteria: 1.A history of psychiatric disease (schizophrenia); 2.HPA axis disease; 3.Contraindications to neuraxial analgesia, such as diseases of the central nervous system (e.g., poliomyelitis, cerebrospinal meningitis, encephalitis), spinal or intraspinal diseases (e.g., trauma or surgery of spinal column, intraspinal canal mass, lumbar disc herniation), systematic infectious diseases (e.g., sepsis, bacteraemia), infection of skin or soft tissue at the site of puncture, and coagulopathy; 4.Severe obstetric comorbidity, can not delivery vaginally.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of offspring neurodevelopmental delay at age 24 months; | — |
Secondary
| Measure | Time frame |
|---|---|
| Prevalence of offspring neurodevelopmental delay at age 6 and 12 months;Maternal fever rate during delivery;Incidence of infant infection(within postpartum 3 days);The incidence of PPD at 6weeks, 6months,12 months and 24 months;Histological chorioamniotic inflammation;The Apgar score of newborns is less than 8 in 1 minute and 5 minutes after birth; | — |
Countries
China
Contacts
Public ContactDing Ting
Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital
Outcome results
None listed