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The immune-cell signature of persistent inflammation, immunosuppression, and catabolism syndrome

The immune-cell signature of persistent inflammation, immunosuppression, and catabolism syndrome

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100048148
Enrollment
Unknown
Registered
2021-07-04
Start date
2021-07-01
Completion date
Unknown
Last updated
2024-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PICS, Sepsis

Interventions

PICS group:none
sepsis group:none
Healthy control group:none

Sponsors

Fudan University Zhongshan Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patient group: (1) Patients with sepsis meet the diagnostic criteria of Sepsis 3.0: 1. Life-threatening organ dysfunction due to dysregulation of the host response due to infection, and the sequential organ failure (SOFA) score was used to evaluate organ dysfunction, That is, sepsis is infection + SOFA score (cardiovascular system function >= 1 point or any other system function score >= 2 points); (2) The patient meets the diagnostic criteria of PICS: 1) ICU stay > 14 days; 2) C-reactive protein (CRP) > 150µg/dL; 3) Lymphocyte count (LYM) 10% or body mass index (BMI) <18kg/m2. 2. The control group is healthy volunteers (HV): healthy volunteers in the physical examination center; 3. Aged 18 to 90 years.

Exclusion criteria

Exclusion criteria: 1. Immunodeficiency patients; 2. Being receiving immunomodulatory treatment (steroids, chemotherapy or biological immunomodulators, etc.).

Design outcomes

Primary

MeasureTime frame
normal information;scRNA-seq results;—

Countries

China

Contacts

Public ContactSun xingfeng

Fudan University Zhongshan Hospital

xfsunok@126.com+86 21 64041990

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026