general anesthesia
Conditions
Interventions
Experimental group:Remimazolam Tosilate injection
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. ASA i-ii level; 2. Age > 65 years old; 3.BMI18~28; 4. Gender is not limited; 5. Patients who plan to undergo general anesthesia on an elective basis.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Abnormal renal function (urea nitrogen >=1.5xULN, serum creatinine greater than the upper limit of normal); 3. Hypovolemia, shock or coma; 4. Uncontrolled hypertension (systolic blood pressure>160mmHg, diastolic blood pressure>90mmHg), suffering from mental system disease and long-term history of taking psychotropic drugs; coronary heart disease; 5. Cerebrovascular disease; 6. Severe arrhythmia; 7. Cognitive dysfunction; 8. Those who are allergic to or have contraindications to the components of benzodiazepines; 9. Pregnant or lactating female patients; 10. Have a history of drug dependence; 11. Have used other sedative drugs in the past week; 12. Participated in drug clinical trials as subjects within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| success rate of sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;heart rate;mood;use of drug during induction;depth of sedation;adverse reaction;time;Intraoperative awareness;degree of satisfaction;dream; | — |
Countries
China
Contacts
Public ContactXia Zhongyuan
Renmin Hospital of Wuhan University
Outcome results
None listed