foot and ankle surgery
Conditions
Interventions
Experimental group 1:10mg dexamethasone and 0.375% ropivacaine for 30ml
Experimental group 2:A total of 0.75µg/kg dexmedetomidine and 0.375% ropivacaine were 30ml
Control group:0.375% ropivacaine 30ml
Sponsors
Beijing Tongren Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 18 to 75 years who are going to undergo elective ankle surgery under general anesthesia in Beijing Tongren Hospital; 2.ASA 1-3 subjects; 3.For subjects who underwent single foot surgery, the estimated operation time was 0-3 hours; 4.Subjects with BMI 18-30 kg / m^2; 5.The subjects who agreed to participate in this study and signed the informed consent before operation.
Exclusion criteria
Exclusion criteria: 1.Subjects with contraindications to anesthesia (coagulation disorder, puncture site infection, allergy to general or local anesthetics); 2.Subjects with predictable difficult airway; 3.Subjects with central or peripheral neuropathy; 4.Pregnant women and lactating women; 5.Patients with long-term opioid use; 6.Patients with abnormal liver and kidney function: ALT and / or AST > 2 x ULN, or TBIL >= 1.5 x ULN; Serum creatinine > 112 µmol/L, Or received dialysis treatment within 28 days before operation; 7.Patients with diabetes who were not satisfactorily controlled (fasting glucose >= 11mmol/L) during screening period; 8.Subjects who participated in other clinical trials within 30 days; 9.Patients with tumor; 10.Patients with Charcot osteoarthropathy; 11.Patients with a long history of hormone use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time of first onset of pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score at each time point;Opioid side effects;Bradycardia occurred during surgery;Patient satisfaction;Complications associated with nerve block;Hypotension;Total opioid consumption;Time to first request analgesia; | — |
Countries
China
Contacts
Public ContactWang Guyan
Beijing Tongren Hospital Affiliated to Capital Medical University
Outcome results
None listed