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Clinical effect and mechanism of Shenan decoction in the treatment of diabetic nephropathy:A Randomized Controlled Clinical trial study Protocol

Clinical effect and mechanism of Shenan decoction in the treatment of diabetic nephropathy

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100048078
Enrollment
Unknown
Registered
2021-06-30
Start date
2021-08-21
Completion date
Unknown
Last updated
2022-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Nephropathy

Interventions

Sponsors

Affiliated Hospital of Changchun University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. It also meets the syndrome differentiation criteria of Chinese medicine for thirst dissipating nephropathy (deficiency of both Qi and Yin combined with stasis and toxin), Western medicine diagnostic criteria for type 2 diabetes and diabetic nephropathy (stage IV). 2. Aged 18 to 70 years,Male or Female; 3. Fasting blood glucose was less than 11.0mmol/L and 2h postprandial blood glucose was less than 15mmol/L;HbA1c does not exceed 8.0%; 4. GFR > 60ml/min and 24-hour urinary protein quantification < 5.0g/24h, systolic blood pressure is controlled in 140-90mmHg, diastolic blood pressure is controlled in 90-60mmHg; 5. Patients were informed and voluntarily participated in the experimental study and signed the consent form, showing good compliance.

Exclusion criteria

Exclusion criteria: 1. Suffering from mental disorders who are unable to cooperate with treatment and cannot follow the medical advice and receive treatment on time; 2. With recent acute complications and combined infection; 3. Women who are pregnant, lactating or preparing to become pregnant, or who are allergic to the drug used in the test; 4. Have received hemodialysis and kidney transplantation.

Design outcomes

Primary

MeasureTime frame
FBG(fasting blood-glucose);PBG(FBG(fasting blood-glucose));Symptom score;Glycosylated hemoglobin;Scr;Glomerular filtration rate; Urinary protein quantification;Proteomics;Metabonomics;

Secondary

MeasureTime frame
Total cholesterol;Triglyceride;LDL;HDL;

Countries

China

Contacts

Public ContactLiu Le

Changchun University of Chinese Medicine

707993226@qq.com+86 15567763962

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026