Non-alcohol fat liver disease (NAFLD)
Conditions
Interventions
Group A:Structured exercise
Group B:Diet intervention
Group C:Structured exercise+diet intervention
Group D:NA
Sponsors
Beijing Pinggu Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Being diagnosed as NAFLD (intrahepatic content of lipid >=5% by QCT);(refer to the world gastroenterology Organization (wgo) global guidelines for NAFLD and nonalcoholic steatohepatitis published in July 2014) 2. Aged 18 to 65 years old; 3. Willing to participate in the study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Chronic liver disease (viral, autoimmune, drug-induced injury) or serious impairment of liver function (>=2 times the normal upper limit of ALT/AST); 2) Severe comorbidities: myocardial infarction, uncontrolled hypertension defined as systolic blood pressure> 140mmHg and/or diastolic blood pressure >=90mmHg, chronic heart failure (New York Heart Association grade III/IV),chronic renal insufficiency (creatinine elevation) ,unstable or severe angina; 3) Poorly controlled type 2 diabetes (HbA1c >9.0% or FPG>11.1mmol/L), diabetes course >5 years or with sever complications;and other types of diabetes; 4) Participating in the weight loss study within 3 months; Participate in other clinical trials within one month; 5) Chronic diarrhea or history of intestinal diseases (such as roemheld syndrome, severe hernia, intestinal obstruction, postoperative intestinal surgery and intestinal ulcer) or diseases that may worsen due to flatulence; 6) Excessive alcohol consumption (defined as weekly alcohol consumption >210g for men and >140g for women in past 6 months); 7) Any other patients considered unsuitable by the researchers (such as chronic consumptive diseases such as malignant tumor, tuberculosis, hematological diseases, mental diseases, autoimmune diseases, acute cerebrovascular diseases within the past 6 months, and those who are not suitable for exercise, such as limb disorders, or bone and joint diseases); 8) Women with fertility (18-50 years old or less than 1 year after menopause) were positive for hCG at baseline, or breast-feeding, unwilling to use appropriate contraceptives; 9) Allergic to ingredients of diet intervention; 10) Drug abusers in 2 years; 11) Used weight-loss substances, antibiotics or intestinal flora regulator in 4 weeks; 12) According to PAR-Q + questionnaire, people who are not suitable for exercise intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intrahepatic content of lipid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Weight;Waist hip ratio;Blood sugar;Four Serum Lipid Indexes;Insulin;ALT/AST;Serum creatinine;HbA1c;Total bilirubin;Physical compositions;Grip strength;Back strength;The gut hormone;Gut flora;30-secondChairStandTest,30sCST;Creatine kinase ( CK)?Creatine kinase isoenzyme(CKMB); | — |
Countries
China
Contacts
Public ContactLi Yufeng
Beijing Pinggu Hospital
Outcome results
None listed