Healthy volunteer
Conditions
Interventions
Case series:Disulfiram oral, 250 mg daily after dinner
Sponsors
Department of Gastroenterology, Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Take 33 healthy people who volunteered to participate in the study in the Second Affiliated Hospital of the Army Military Medical University as the source of the research objects.
Exclusion criteria
Exclusion criteria: 1. People suffering from alcoholic fatty liver disease; 2. Those suffering from severe renal dysfunction; 3. According to the judgment of the investigator, there is a clinically significant medical condition that may affect research participation and/or personal health, including but not limited to the following conditions: (1) Medical history of cardiovascular and cerebrovascular disease events in the past 6 months; (2) Anticoagulant therapy is needed; (3) Gastrointestinal diseases include but are not limited to the following diseases: pancreatitis, inflammatory bowel disease or other diseases related to malabsorption or persistent abdominal discomfort; (4) Endocrine diseases other than type 2 diabetes and hypothyroidism; (5) Chronic infection (for example, tuberculosis, HIV infection, hepatitis A virus, hepatitis B virus or hepatitis C virus); (6) Neurological or mental diseases that hinder the effective implementation of informed consent or may interfere with the subject's compliance with the research procedures (for example, severe depression in the last 2 years, suicidal behavior in the last 3 months); (7) Medical history of other mental illnesses, including schizophrenia and bipolar disorder; 4. Those who have recently taken multiple drugs for the treatment of diseases, such as: (1) Metronidazole, isoniazid, theophylline, tinidazole; (2) Seizure drugs: such as phenytoin (dilantine); (3) Blood thinning drugs (including warfarin, coumarin, Yantofen), isoniazid, etc.); 5. Those who have recently consumed any alcohol-containing food or used alcohol-containing products (such as mouthwash, cough suppressant, cooking wine, certain desserts, colognes, perfume, antiperspirants, antiseptic astringent skin products, hair dyes, etc.). 6. Those who are pregnant or breastfeeding; 7. Participated in a weight loss plan within the past 3 months; 8. Weight change in the past month =5%; 9. Donated blood within 3 months before screening, or plan to donate blood during the study period; 10. Those who have not signed the informed consent and or the research process has not been completed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diversity and structure of gut microbiota;Key metabolites of gut microbiota; | — |
Countries
China
Contacts
Public ContactYang Shiming
The Second Affiliated Hospital of Army Medical University
Outcome results
None listed