Hypercholesterolemia atherosclerotic cardiovascular disease
Conditions
Interventions
high-altitude versus plain hyperlipidemia populations:Atorvastatin Calcium (Lepu Medical)
Sponsors
The 940 Hospital of the Joint Logistics Support Force
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients who take atorvastatin calcium tablets clinically to regulate blood lipid levels and prevent ASCVD; 2. Continuously taking atorvastatin calcium tablets for more than 5 half-lives to reach steady-state blood drug concentration; 3. Aged 18 to 85 years old.
Exclusion criteria
Exclusion criteria: 1. Patients with malignant tumors; 2. Patients who have undergone major surgery in the past year; 3. People with a history of alcohol or drug abuse; 4. Patients with pregnancy plans or pregnancy test positive and lactating patients during the trial; 5. Patients with obvious symptoms and signs of liver and kidney disease, or patients with ALT and AST higher than 1.5 times the upper limit of normal; 6. Patients with serum creatinine greater than 1.5 times the upper limit of normal; 7. Patients who have or have had rhabdomyolysis or myopathy or creatine kinase (CK) greater than 3 times the upper limit of normal; 8. Patients who are allergic to atorvastatin and the excipients added to the drug; 9. The same administration of cytochrome P4503A4 (CYP3A4) strong inhibitors, fibric acid derivatives, lipid-adjusted doses of niacin, protease inhibitors, itraconazole, clarithromycin, erythromycin, cyclosporine, efib Viren, amlodipine, diltiazem, rifampicin, warfarin, colestipol, grapefruit juice, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LDL-C; | — |
Countries
China
Contacts
Public ContactWang Rong
940 Hospital of Joint Service Support Force
Outcome results
None listed