Non-infectious Uveitis
Conditions
Interventions
Case series:Baricitinib
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 60 years old; 2. According to the diagnostic criteria of refractory NIU, patirnts should meet one of the following items 2, 3 and 4 on the basis of Item 1: (1) Non infective intermediate uveitis, posterior uveitis or panuveitis; (2) While receiving at least one common immunosuppressant, it is difficult to reduce glucocorticoids; (3) The patients were intolerant to glucocorticoids or immunosuppressants due to side effects; (4) The newly diagnosed patients with VKH or Behcet's disease-related uveitis need long-term immunosuppressive therapy; 3. Active uveitis disease must be present at day 1/baseline, and more than one of the following conditions is required: (1) Active, inflammatory, chorioretinal and/or inflammatory retinopathy; (2) Anterior chamber cells >=2 + (evaluated according to SUN criteria); (3) Inflammatory vitreous opacity >=2 + (evaluated according to SUN criteria).
Exclusion criteria
Exclusion criteria: 1. Patients had no willingness to participate in the clinical trial; 2. Dignosis of infectious uveitis, such as viral uveitis, tuberculous uveitis, fungal infection and Toxoplasma gondii infection, or can not be excluded; 3. Complicated with severe glaucoma and complicated cataract; 4. Systemic screening combined with tuberculosis and hepatitis B, and without standardized anti-tuberculosis and anti-hepatitis B virus treatment; 5. Combined with uncontrolled systemic diseases such as hypertension, diabetes; 6. Liver and kidney dysfunction; 7. Pregnant women and lactation; 8. Previous severe cardiovascular and cerebrovascular diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vision; | — |
Countries
China
Contacts
Public ContactSun Xufang
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed