Liver ischemia reperfusion injury
Conditions
Interventions
Ischemic preconditioning group:Acute isovolumetric hemodilution via radial artery causes ischemic preconditioning
Control group:Acute isovolumetric hemodilution via the internal jugular vein without ischemic preconditioning
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing hepatectomy under general anesthesia with tracheal intubation, hepatic portal blockade during the operation and low central venous pressure is required; 2. ASA classification is I to III; 3. Positive bilateral Allen test: less than 10s; 4. Aged 18 to 70 years old; 5. Body mass index (BMI): 18.5kg/m2-30.0kg/m2.
Exclusion criteria
Exclusion criteria: 1. Combined with severe liver and kidney dysfunction (alanine aminotransferase>50U/L, aspartate aminotransferase>50U/L; blood creatinine>200µmol/L, blood urea nitrogen>9mmoml/L); 2. Preoperative anemia: male hemoglobin <100g/L, female hemoglobin <90 g/L; 3. Abnormal coagulation function: prothrombin time: PT=17.3 seconds; plasma partial thromboplastin time: APTT=50 seconds; fibrinogen FIB=1.5g/L; platelet PLT=100 x 109/L; 4. Patients infected at the puncture site; 5. Patients who cannot cooperate with the study for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alanine aminotransferase;Aspartate aminotransferase; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bilirubin;Blood perfusion index; | — |
Countries
China
Contacts
Public ContactTang Jing
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed