Cerebral Ischemic Stroke
Conditions
Interventions
Test group:Intra-arterial injection of cord blood mononuclear cells before thrombectomy
Control group:Intra-arterial injection of saline before thrombectomy
Sponsors
Liaocheng People's Hospital
Eligibility
Sex/Gender
All
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Diagnose AIS and present clinical symptoms and signs of acute ischemic stroke; 2. It is diagnosed as acute large vessels by imaging (lesions are in ICA, MCA-M1, MCA-M2); 3. Aged 35 to 70 years old; 4. Subjects or their guardians voluntarily sign informed consent; 5. NIHSS 2-25 points, mRS =6 points after admission, blood glucose 2.78 -22.2 mmol, INR =30x10^9/L.
Exclusion criteria
Exclusion criteria: 1. Before the onset of mRS score >=2, baseline NIHSS score 25; 2. CT or MRI examination of the head has the following evidence: significant space-occupying effect and midline shift. Intracranial tumors other than small meningiomas. Evidence of intracranial hemorrhage; 3. Severe head injury and residual neurological deficit within 90 days before the onset; 4. Suffer from neuropsychiatric diseases that may affect the evaluation of neurological function, such as dementia treated with cholinesterase inhibitors (such as donepezil); 5. Life expectancy 3; 7. Patients with co-infection, malignant tumors or hematological diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 90-day mRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serological indicators;Post-surgery 24h NIHSS score;Post-surgery 7d NIHSS score;TICI grade;Barthel Index;Median lesion volume on CT;Death;Asymptomatic intracranial hemorrhage;Symptomatic intracranial hemorrhage;Infarction in new territory at 5–7 days;Postoperative complications; | — |
Countries
China
Contacts
Public ContactZhang Liyong
Liaocheng People's Hospital
Outcome results
None listed