Rectal Cancer
Conditions
Interventions
Gold Standard:Clinical outcome
Sponsors
Beijing Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged over 18 years; 2. An Eastern Cooperative Oncology Group (ECOG) performance status of 0–1; 3. Pre-treatment magnetic resonance (MR) examination (including a T2-weighted [T2W] sequence); 4. Clinical stage T3 to T4, or any stage T and N+ tumors without distant metastasis (based on the 7th edition of the American Joint Committee on Cancer); 5. Histologically confirmed rectal adenocarcinoma with biopsy sample; 6. Preoperative chemoradiotherapy and radical surgery in Beijing Cancer Hospital; 7. Long-term (>2 years) follow-up in case of patients underwent radical surgery; 8. Long-term (>2 years) follow-up in case of a wait-and-see program for those with clinical complete response(cCR) and the reference criteria for assessment of cCR included the Sao Paulo Schema, European Society for Medical Oncology (ESMO) Schema, and Memorial Sloan Kettering Regression Schema.
Exclusion criteria
Exclusion criteria: 1. Second malignancies; 2. Patients lost to follow-up; 3. Poor-quality of MRI images or incomplete data; 4. Recurrent rectal cancer; 5. History of pelvic radiation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor Regression Grade(TRG); | — |
Secondary
| Measure | Time frame |
|---|---|
| ypT,ypN;Disease Free Survival(DFS); | — |
Countries
China
Contacts
Public ContactWang Weihu
Cancer Hospital of Beijing University
Outcome results
None listed