1H-MRS detects the brain tissue metabolism of severe skeletal Class II malocclusion and the mechanism of its association with upper airway physiology

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100048003

Enrollment

Unknown

Registered

2021-06-28

Start date

2022-01-01

Completion date

Unknown

Last updated

2022-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive sleep apnea and hypo-apnea syndrome ,OSAHS

Interventions

Test group :orthodontics-orthognathic combined therapy+masked orthodontic treatment

Control group:Nil

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Bone Class I; 2. Severe Bone Class II; 3. Aged 18 to 45 years old.

Exclusion criteria

Exclusion criteria: 1. BMI> 30; 2. Accompanied by systemic diseases such as diabetes, hypertension, cardiovascular and cerebrovascular diseases; 3. Combined with cleft lip and palate; 4. Combined withtonsil and adenoid diseases.

Design outcomes

Primary

Measure	Time frame
ANB;Pog-NPerp;S-Go/N-Me;Sum;APDI;Pog’-TVL;C-Me’;The distance from the point on the hyoid bone to the vertical reference plane;The distance from the point on the hyoid bone to the horizontal reference plane;The distance from the upper point of the hyoid bone to the lowermost point of the third cervical vertebra;The distance from the suprahyoid point to the submental point;The vertical distance from the upper point of the hyoid bone to the mandibular plane;Upper airway pattern;Polysomnography;Epworth Sleepiness Score;Metabolites in brain tissue;	—

Measure

Time frame

ANB;Pog-NPerp;S-Go/N-Me;Sum;APDI;Pog’-TVL;C-Me’;The distance from the point on the hyoid bone to the vertical reference plane;The distance from the point on the hyoid bone to the horizontal reference plane;The distance from the upper point of the hyoid bone to the lowermost point of the third cervical vertebra;The distance from the suprahyoid point to the submental point;The vertical distance from the upper point of the hyoid bone to the mandibular plane;Upper airway pattern;Polysomnography;Epworth Sleepiness Score;Metabolites in brain tissue;

—

Countries

China

Contacts

Public ContactGuo Jing

Ningbo Stomatology Hospital

guojing@sdu.edu.cn+86 574 56121719

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026