Alzheimer disease
Conditions
Interventions
MCI group:Nil
AD group:Nil
Normal cognitive group:Nil
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.MCI group: According to the diagnostic criteria for MCI in the 2018 Chinese Dementia and Cognitive Impairment Diagnosis and Treatment Guidelines, refer to the standards set by Professor Peterson of the Moyo Clinic in the United States in 1999. The details are as follows: (1)The main complaint of memory impairment (the main complaint of the patient or confirmed by family members), the course of disease >=6 months; (2)Impairment of objective memory: The 20-minute delayed recall score of the Auditory Word Learning Test (AVLT) is less than or equal to the demarcation score of the corresponding age group (60-69 years old, 3 points; 70-79 years old, 2 points); (3)Overall Normal cognitive function: Mini Mental State Scale (MMSE) >= 24, Mattis Dementia Rating Scale (MDRS. 2)> 120; (4)Normal or slightly impaired daily living ability: Daily Living Ability Assessment Scale (ADL) score Within the normal range of age and education level; (5)No dementia, does not meet the American neurology, language impairment and stroke, senile dementia and related diseases related to dementia diagnostic criteria (NINCDS/ADRDA); (6)Exclude cognitive impairment caused by psychiatric and vascular factors: HDRS<17, HIS<=4, no lesions in the cortex, asymptomatic subcortical infarcts with a diameter of <= 1cm, and not located in the hippocampus, head of the caudate nucleus, and thalamus Inside the back. Each patient was diagnosed and approved by two physicians with senior professional titles who belonged to the neurology department of cognitive impairment; 2.AD group: According to the diagnostic criteria for AD in the 2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment, refer to the 2011 National Institute of Aging and Alzheimers Association Revised Edition (NIA-AA) for the probable AD dementia criteria, The details are as follows: (1) Core clinical criteria: 1)Meet the diagnostic criteria for dementia; 2)Insidious onset, with symptoms gradually appearing over several months to several years; 3)Having a clear history of cognitive impairment; 4)Expressing amnestic syndrome (learning and Decreased near memory, accompanied by impairment of one or more other cognitive domains, or non-amnestic syndrome (impairment of one of the three of language, visual space, or executive function, accompanied by impairment of one or more other cognitive domains); (2) Exclusion criteria: 1)With a history of stroke related to the occurrence or deterioration of cognitive impairment, or with multiple or extensive cerebral infarctions, or with severe white matter lesions; 2)With the core symptoms of Lewy body dementia; 3)With frontotemporal dementia Significant characteristics of the disease; 4)Significant characteristics of primary progressive aphasia; 5)Other neurological diseases that cause progressive memory and cognitive impairment, or non-neurological diseases, or evidence of medication; (3) Supporting criteria: 1)In the evaluation based on the information provided by the insider and obtained from formal neuropsychological tests, evidence of progressive cognitive decline was found; 2)Evidence of mutations in disease-causing genes (APP, PS1 or PS2) was found; (4)Some patients also have evidence of AD pathological changes in the body (one of the following): 1)Decrease of Aß1-42 level in cerebrospinal fluid and increase of T-tau or P-tau protein level; 2)Amyloid PET imaging, tracer Increased retention; 3. T
Exclusion criteria
Exclusion criteria: 1. Those who do not agree to participate in this research; 2. Serious complications of diabetes; 3. Liver cirrhosis; 4. Hyperthyroidism; 5. Parkinson's disease; 6. Severe anxiety and depression; 7. Post-traumatic stress syndrome; 8. Severe physical illness; 9. Clinical history of stroke or stroke: MRI or CT of the head has lesions with a diameter of >= 2 mm (if there are imaging evidence of lacunar infarctions under the cortex, periventricular and deep brain, except those with asymptomatic and corresponding medical history), HIS>4 points.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Tau protein;glycoprotein;DNA; | — |
Primary
| Measure | Time frame |
|---|---|
| Aß protein; | — |
Countries
China
Contacts
Public ContactChen Lifang
Shenzhen Second People's Hospital
Outcome results
None listed