The regulation mechanism of dmPFC and dlPFC on the maintenance of abnormal emotional representation in adolescents with schizophrenia or major depression disorder

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100047987

Enrollment

Unknown

Registered

2021-06-28

Start date

2021-07-01

Completion date

Unknown

Last updated

2022-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

schizophrenia/Major Depression Disorder

Interventions

Schizophrenia group1:fNIRS neuralfeedback training with dmPFC as target brain region

Schizophrenia group2: fNIRS neuralfeedback training with dlPFC as target brain region

Schizophrenia group3:Sham training

Major Depressive Disorder1:fNIRS neuralfeedback training with dlPFC as target brain region

Major Depressive Disorder2:fNIRS neuralfeedback training with dmPFC as target brain region

Major Depressive Disorder3:Sham training

Subclinical depression group1:fNIRS neuralfeedback training with dlPFC as target brain region

Subclinical depression group2:fNIRS neuralfeedback training with dmPFC as target brain region

Subclinical depression group3:Sham training

Eligibility

Sex/Gender

All

Age

12 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1.Schizophrenia: (1)DSM-V, Schizophrenia; (2)Age between 13 and 18 or onset before 18 years; (3)Right handed; 2.MDD: (1)DSM-5 or ICD-10,depressive episode; (2)Aged from 12 to 50 years; (3)IQ>70; (4)Course of disease70.

Exclusion criteria

Exclusion criteria: 1.Schizophrenia: (1)History of brain trauma; (2)Other psychotic disorders or substance abuse; (3)Psychotic medication changed over the past 8 weeks; (4)MECT over the past 8 weeks; (5)Metal object in the body; 2.Depression: (1)8 weeks of MECT; (2)8 Significant adjustment of antipsychotics within weeks; (3)Perinatal trauma; (4)Substance and/or alcohol abuse; (5)Combination of other Axis I mental disorders; (6)A history of partial brain injury or neurological disease; 3.Subclinical depression: (1)All mental disorders or personality disorders with a DSM-V diagnosis/ICD-10; (2)Perinatal trauma; (3)Substance and/or alcohol abuse; (4)A history of local brain injury or neurological disease.

Design outcomes

Primary

Measure	Time frame
Clinical evaluation;Behavioral task;Magnetic Resonance Imaging;	—

Secondary

Measure	Time frame
Scale scores;Blood oxygen signal based on fNIRS;	—

Countries

China

Contacts

Public ContactYan Chao

School of Psychology and Cognitive Science, East China Normal University

cyan@psy.ecnu.edu.cn+86 21 62230119

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026