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Study of esophageal mucosa injury mechanism in gastroesophageal reflux disease based on pepsin

Study of esophageal mucosa injury mechanism in gastroesophageal reflux disease based on pepsin

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100047985
Enrollment
Unknown
Registered
2021-06-28
Start date
2021-07-01
Completion date
Unknown
Last updated
2022-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastroesophageal reflux disease

Interventions

Control group:Nil
Non-erosive reflux disease group:Nil
Reflux esophagitis group:Nil

Sponsors

The Second Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with reflux related symptoms from the Second Affiliated Hospital of Chongqing Medical University; 2. Aged from 18 to 70 years, gender is not limited; 3. Volunteer to participate in this study, and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Cardiopulmonary insufficiency, cerebral apoplexy, obvious thoracic and abdominal aneurysm or in shock and coma and other patients who cannot tolerate examination; 2. Patients with suspected gastrointestinal bleeding, perforation, peritonitis, ascites and severe abdominal distension; 3. Cervical trauma, spinal deformity; 4. Patients with hemorrhagic diseases (including abnormal coagulation function); 5. Addiction and dependence of opioids or hypnotic drugs and long-term alcoholics; 6. Uncooperative, unable to communicate and suffering from neuropsychiatric diseases; 7. Corrosive inflammation of the upper digestive tract; 8. Pregnant or lactating woman; 9. People who are extremely uncooperative (mental abnormality, severe mental retardation); 10. People anesthetic drug allergy history or allergy constitution person; 11. Other researchers discussed the situation that they could not participate in the study.

Design outcomes

Primary

MeasureTime frame
saliva pspsin concentration;

Countries

China

Contacts

Public ContactYang Zhaoxia

The Second Affiliated Hospital of Chongqing Medical University

yangzhx2003@163.com+86 13637896168

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026