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Aldosterone Chemiluminesscene Immunoassay-Specific Threshold Values in the Captopril Challenge Test for Diagnosing Primary Aldosteronism

Aldosterone Chemiluminesscene Immunoassay-Specific Threshold Values in the Captopril Challenge Test for Diagnosing Primary Aldosteronism

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100047984
Enrollment
Unknown
Registered
2021-06-28
Start date
2021-07-01
Completion date
Unknown
Last updated
2022-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary aldosteronism

Interventions

aldosterone&#32
measurement.
Gold Standard:Clinical manifestations and saline infusion test or captopril challenge test with liquid chromatography coupled to tandem mass spectrometry based aldosterone measurement.
Index test:The&#32
captopril&#32
challenge&#32
test&#32
with&#32
chemiluminescence&#32
immunoassays&#32
based&#32

Sponsors

The First Affiliated Hospital, Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Patients with hypertension(systolic blood pressure >=140 mmHg and/or diastolic blood pressure >=90 mmHg obtained on 3 separate occasions after relaxing in a sitting position); 2.Plan to perform the captopril challenge test or saline infusion test.

Exclusion criteria

Exclusion criteria: 1.Refuse to participate in our study; 2.Age <18 years old.

Design outcomes

Primary

MeasureTime frame
Area under ROC curve;Sensitivity;Specificity;—

Countries

China

Contacts

Public ContactCao Xiaopei

The First Affiliated Hospital, Sun Yat-sen University

caoxp@mail.sysu.edu.cn+86 13802503792

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026