Evaluation of the effect of esketamine combined with sufentanil on postoperative analgesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100047881

Enrollment

Unknown

Registered

2021-06-27

Start date

2021-06-30

Completion date

Unknown

Last updated

2022-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain

Interventions

test group:Sufentanil (5µg/kg) + esketamine (0.5mg/kg) + granisetron 6mg + 0.9% sodium chloride injection mixed to prepare a 100ml solution

Control group:Sufentanil (5µg/kg)+esketamine (1.0mg/kg)+granisetron 6mg+0.9% sodium chloride injection were mixed to prepare a 100ml solution.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 65 years, no gender limit; 2. Patients undergoing orthopedic surgery and thoracotomy; 3. The ASA score is I~III; 4. BMI 18 to 30kg/m2; 5. No history of drug allergy.

Exclusion criteria

Exclusion criteria: 1. Patients with contraindications to general anesthesia; 2. Patients who meet the contraindications of the trial drug; 3. Patients deemed inappropriate by the investigator; 4. Patients with cognitive impairment or unable to cooperate with pain score due to abnormal mental or neurological function; 5. Participated in drug clinical trials as subjects within the past 3 months.

Design outcomes

Primary

Measure	Time frame
pain score;	—

Countries

China

Contacts

Public ContactLiu Chuanguo

Chengdu Public Health Clinical Medical Center

jackey_lcg@163.com+86 13540602705

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026