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The benefit of dapagliflozin on cardiorespiratory fitness in coronary heart disease patients with type 2 diabetes undergoing percutaneous coronary intervention

The benefits of dapagliflozin on cardiorespiratory fitness and vascular endothelial cell function in coronary heart disease patients with type 2 diabetes undergoing percutaneous coronary intervention

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100047856
Enrollment
Unknown
Registered
2021-06-27
Start date
2021-07-01
Completion date
Unknown
Last updated
2022-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery disease

Interventions

Group A:standardized medication, including antiplatelet, beta blockers, angiotensin II receptor blockers, statins,antidiabetic agents exclusive of dapagliflozin, and so on.
Group B:standardized medication, including antiplatelet, beta blockers, angiotensin II receptor blockers, statins,antidiabetic agents inclusive of dapagliflozin, and so on.

Sponsors

Yuebei People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Aged 18 to 80 years; 2.the CHD patients with type 2 diabetes undergoing percutaneous transluminal coronary intervention.

Exclusion criteria

Exclusion criteria: Obvious abnormal liver and kidney function,allergic to net of Glenn composition, New York heart function class III - IV, bronchial asthma, interstitial lung disease, unable to cooperate with movement or refuse to accomplish cardiopulmonary exercise testing

Design outcomes

Primary

MeasureTime frame
maximal oxygen uptake;Endothelium dependent vasodilatation function,FMD;

Secondary

MeasureTime frame
oxygen uptake at anaerobic threshold;VO2/HR at maximal oxygen uptake;minute ventilation/carbon dioxide production,VE/VCO2;HRR in a minute;blood lipid;Uric acid;Homocysteine;The incidence of adverse cardiovascular events;Incidence of adverse reactions;

Countries

China

Contacts

Public ContactLiu Xiangyang

Yuebei People's Hospital

longliu0714@sina.com+86 13553640790

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 27, 2026