Gastrointestinal disease
Conditions
Interventions
control group:Sedation with propofol injection
Sponsors
The Fifth Hospital of Xiamen
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years; 2. American Anesthesiologist Classification (ASA) I-II; 3. Patients who electively undergo painless gastroscopy and/or colonoscopy; 4. Body mass index (BMI) >=18 and =10 and =95% when breathing air; systolic blood pressure (SBP) >=90mmHg and =60mmHg and =55 and <=100 beats/min; 6. Be able to understand the research process and methods, and voluntarily participate in this research.
Exclusion criteria
Exclusion criteria: 1. Those with contraindications to general anesthesia or those who have had a history of anesthesia accident in the past; 2. Known or suspected allergies or contraindications to propofol injection, cyclopofol injection excipients, benzodiazepines, opioids, muscle relaxants, etc.; 3. Patients with acute upper respiratory tract infection, asthma attack or acute severe laryngeal disease; 4. There is a history of gastrointestinal disease: gastrointestinal retention, active bleeding, conditions that may lead to reflux and aspiration; 5. Complicated with craniocerebral loss, intracranial hypertension, stroke, history of cerebrovascular accident, etc.; 6. Respiratory insufficiency, obstructive pulmonary disease, difficult airway or judged to be difficult for endotracheal intubation (modified Markov score grade III or IV); 7. Uncontrolled hypertension, hypotension and diabetes; 8. Severe arrhythmia, heart failure, unstable angina, myocardial infarction, etc.; 9. Severe liver dysfunction or severe renal insufficiency; 10. History of alcoholism or drug dependence; 11. Abuse or long-term use of narcotic, sedative and analgesic drugs; 12. Those who have a history of mental illness in the past; 13. Those who have participated in any drug clinical trials within 1 month before screening; 14. Pregnant and lactating women; fertile women or men who are unwilling to use contraception throughout the trial period; subjects (including male subjects) who have a pregnancy plan within 1 month after the trial; 15. Subjects who are considered by the investigator to have any other factors that are not suitable for participating in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Onset time;wake up time;Diagnosis success rate; | — |
Countries
China
Contacts
Public ContactRao Rong
The Fifth Hospital of Xiamen
Outcome results
None listed