Patients with mechanical ventilation and need sedation after ICU operation
Conditions
Interventions
Group 2:Propofol
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years, male or female; 2. Transfer to ICU after operation; 3. Tracheal intubation or tracheotomy and mechanical ventilation are required, and ventilation and sedation are expected to be required for at least 6 hours after randomization; 4. Sedation needs are mild to moderate sedation; 5. The subject himself or his legal representative agrees and signs a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with myasthenia gravis, schizophrenia, severe dementia, and severe depression in the past; 2. Those who are allergic to benzodiazepines or propofol in the past; 3. Those with preoperative ASA (American Society of Anesthesiologists) grade II or above (grade I: healthy body, good development and nutrition, normal function of various organs; grade II: mild comorbidities except surgical diseases, and functional compensation is sound , no parenchymal organ function limitation; grade III: severe coexisting disease, limited physical activity, but still able to cope with daily activities, that is, parenchymal organ function limitation, combined with one or more moderate to severe diseases; grade IV: combined severe Illness, loss of daily activities, and often life-threatening; Class V: a dying patient, with no possibility of survival without surgery; Class VI: a patient declared brain-dead, ready to be used as a donor for organ removal and transplantation); 4. Those who are pregnant or breastfeeding; 5. Those who are deemed inappropriate by the investigator to participate in the trial.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Efficacy index; | — |
Countries
China
Contacts
Public ContactPeng Zhiyong
Zhongnan Hospital of Wuhan University
Outcome results
None listed