chronic obstructive pulmonary disease
Conditions
Interventions
Systemic hormones less than 3 days group:Intravenous methylprednisolone (40mg/ day) was used for 1-3 days during hospitalization
Systemic hormones for more than 3 days group: Intravenous methylprednisolone (40mg/ day) was used for 4-7 days during hospitalization
non-systemic hormone group:No systemic hormones were used during hospitalization
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Meet the COPD diagnostic criteria in the GOLD guidelines, and be hospitalized due to acute exacerbation (dyspnea, cough or increased sputum production); 2. Age > 18 years old; 3. Combined or not combined with lower respiratory tract infection; 4. The patient has the ability to communicate in language or writing, agrees to participate in the research and signs the informed consent, and has the ability to complete the relevant examinations of the trial.
Exclusion criteria
Exclusion criteria: 1. Past history of bronchial asthma; 2. Combined with other lung diseases (such as bronchiectasis, lung cancer, interstitial lung disease, pulmonary thromboembolism, etc.); 3. Have used systemic hormones (oral or intravenous) before admission; 4. Invasive ventilation is required; 5. Chronic renal insufficiency, chronic liver disease; 6. Pregnancy: Pregnant or lactating women or women of childbearing potential who are not using acceptable contraception.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fractional exhaled nitric oxide(FENO50+CANO);pulmonary ventilation function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Breathlessness Measurement Using The Modified British Medical Research Council;COPD Assessment Test;Artery Blood Gas;Blood Inflammatory Markers;high-sensitivity C-reactive protein;Serum IgE; | — |
Countries
China
Contacts
Public ContactWu Lili
Shenzhen Second People's Hospital
Outcome results
None listed