Vascular cognitive dysfunction
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. VCI inclusion criteria for patients with T2DM : (1) Conforming to the diagnostic points of T2DM and VCI, and having a history of ischemic or hemorrhagic stroke confirmed by cranial CT or MRI; (2) Cognitive impairment with a Montreal Cognitive Assessment Scale (MOCA - Beijing Version) score =24 points.The clinical dementia scale (CDR) score was 0.5. The clinical dementia scale (CDR) score was 0.5.No significant impairment in daily living activities, instrumental daily living ability scale (IADL) score >=16; (3) can cooperate with the completion of nuclear magnetic functional scanning; (4) The course of stroke ranged from 3 to 12 months; (5) People aged 50 to 60 are right-handed; (6) No speech and language dysfunction; (7) Have not received acupuncture or rehabilitation treatment in the past three months; (8) No diseases or infectious diseases such as depression and mental symptoms; (9) No use of drugs in the following categories within 30 days prior to screening for cognitive impairment: drugs for Alzheimer's disease or dementia, anti-Parkinson's disease drugs, short-acting antianxiety agents, neurosedatives or analgesics, antiepileptics, hormones, drugs with significant cholinergic or anticholinergic side effects. 2. Inclusion criteria for T2DM group with normal cognitive function : (1) meeting the diagnostic criteria for diabetes, and excluding stroke confirmed by cranial CT or MRI; (2) Normal cognitive function, MOCA scale score >=26 points (if the number of years of education =24 points;CDR score was 0;Instrumental Daily Living Scale (IADL) score >=16 points; (3) can cooperate with the completion of nuclear magnetic functional scanning; (4) People aged 50 to 60 are right-handed; (5) No speech and language dysfunction; (6) Have not received acupuncture or rehabilitation treatment in the past three months; (7) No diseases or infectious diseases such as depression and mental symptoms; (8) No use of drugs in the following categories within 30 days before screening for cognitive impairment: drugs for Alzheimer's disease or dementia, anti-Parkinson's disease drugs, short-acting antianxiety agents, neurosedatives or analgesics, antiepileptics, hormones, drugs with significant cholinergic or anticholinergic side effects. 3. Inclusion criteria for healthy volunteers : (1) They did not meet the diagnostic criteria for diabetes and were confirmed by cranial CT or MRI to exclude stroke; (2) Normal cognitive function, MOCA scale score >=26 points (if the number of years of education =24 points;CDR score was 0;Instrumental Daily Living Scale (IADL) score >=16 points; (3) can cooperate with the completion of nuclear magnetic functional scanning; (4) 50 to 60 years old, right-handed; (5) no brain trauma, drug and alcohol dependence may affect the brain structure and function of diseases;No depression, mental symptoms and other diseases.
Exclusion criteria
Exclusion criteria: 1. Subjects with obvious hearing, visual and language impairments affecting cognitive function tests; 2. Acute diabetic complications such as diabetic ketoacidosis and high-level coma in the past 3 months; serious diseases such as heart, lung, liver, kidney and blood system may affect cognitive function; 3. People with central infection, brain tumor or other focal injury affecting cognition; suffering from Alzheimer's disease, Parkinson's disease and other neurological diseases that can cause dementia; history of severe brain trauma with persistent neurological deficits or known structural brain abnormalities; 4. History of alcohol, drug abuse or dependence within the past 2 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| voxel-based morphometry;Superoxide Orgotein Dismutase;Maleic Dialdehyde;brain derived neurotrophic factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal CognitiveAssessment;Revised Wechsler Memory Inventory, Version 4 (Chinese Version);Function Independent Measure; | — |
Countries
China
Contacts
Public ContactGuan Ying
The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
Outcome results
None listed