General Anesthesia
Conditions
Interventions
Four doses groups:remimazolam and propofol
Sponsors
Linfen Central Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.ASA i-ii; 2.Aged 60 to 80 years,no gender limitation; 3.18 kg/m2<=BMI<=30 kg/m2; 4.Voluntary participation in the study and the informed consent signed by the applicant or his legal representative.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to General Anesthesia; 2. There were significant preoperative breath, circulation dysfunction, liver kidney failure, anemia (HB 80< g/l) , Thrombocytopenia(PLT<80 x 10^9/L); 3. Patients with severe neuropsychiatric diseases; 4. Taking benzodiazepine or opioid drugs intermittently for a period of 1 month or for a period of nearly 3 months; 5. Hypersensitivity or contraindication to Benzodiazepine, opioids, propofol, flumazenil, naloxone and other drugs and their components; 6. Assessment of difficult airway (modified Markovian rating scale iv) ; 7. Patients who are participating in other clinical trials; 8. Researchers believe that other reasons are not appropriate for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time from induction of anesthesia to BIS =60;diastolic blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in bispectralindex values over time;Number of remedial treatment cases;Number of cases of using antagonistic drugs;systolic blood pressure;heart rate; | — |
Countries
China
Contacts
Public ContactWang Zhiguo
Linfen Central Hospital
Outcome results
None listed