sepsis
Conditions
Interventions
Experimental group:Critical ultrasonography guided precise fluid management.
Control group:Routine hemodynamic monitoring guided fluid management.
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged >=18 years; 2.The estimated length of ICU stay >=24 hours; 3.Patients who were diagnosed according to the sepsis diagnostic criteria (Sepsis-3) were included in this study: (1) Suspected or confirmed infections based on clinical evidence and/or positive in etiology; (2) The SOFA score (sepsis related organ failure assessment score) was >=2 .
Exclusion criteria
Exclusion criteria: 1.Pregnant; 2.Acute cerebrovascular accident; 3.Acute coronary syndrome; 4.Acute pulmonary edema; 5.Status asthmatics; 6.Malignant arrhythmia; 7.Active gastrointestinal bleeding; 8.Epileptic seizure; 9.Drug poisoning; 10.Severe burns; 11.Contraindications of blood transfusion; 12.Intraperitoneal hypertension (IAP >= 12mmHg and increased continuously); 13.Acute pulmonary embolism; 14.Contraindications of leg raising; 15.The patient or his agent ad litem refuses active treatment; 16.The patient or his agent ad litem refused to participate in this study; 17.The patient are participating in other interventional clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| all-cause 60-day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Failure rate of critical ultrasound monitoring in intervention group;failure rate of conventional monitoring in the control group;total infusion quantity during Intensive Care Unit stay;dosage and duration of vasopressors during Intensive Care Unit stay;Incidence of complications; | — |
Countries
China
Contacts
Public ContactLi Shusheng
Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed