prurigo nodularis
Conditions
Interventions
Case series:No
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years; 2. Has typical clinical manifestation of prurigo nodularis; 3. Has suffered from prurigo nodularis for 3 months; 4. One week before treating with dupilumab, NRS>=7; 5. Number of nodular>=20; 6. Not response to topical corticosteroids, or has the contraindication of topical corticosteroids; 7. Has used emollients for one or two times for more than 5 days in the week before treatment; 8. The patient promise to record the symptoms everyday.
Exclusion criteria
Exclusion criteria: 1. Suffered from other dermatologic disease that might affect the evaluation of efficacy of treatment; 2. Nodularis prurigo induced by medications; 3. Nodularis prurigo induced by neuropathies or psychiatric diseases; 4. Has suffered from atopic dermatitis in 6 months; 5. Any other condition that could affect the efficacy of treatment or evaluation of the efficacy of treatment; 6. Abnormal renal function; 7. Uncontrolled thyroid diseases; 8. Active mycobacterial infection, or previous mycobacterial infection that has not undergone standard treatment; 9. Parasite infection; 10. Has suffered from active infection (e.g. bacterial infection, protozoan infection, viral infection, and fungal infection) in 2 weeks; 11. Immunodeficiency; 12. History of malignancy (except for cervical in situ carcinoma, cutaneous squamous cell carcinoma or basal cell carcinoma that have been cured).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of prurigo nodularis each time;Observe the adverse drug reactions caused by dupilumab; | — |
Secondary
| Measure | Time frame |
|---|---|
| The percentage of patients whose numerical rating scale decrease by not less than 4 at week 8;The percentage of patients whose numerical rating scale decrease by not less than 4 at week 16;The duration from onset of treatment with dupilumab to relief of symptoms.; | — |
Countries
China
Contacts
Public ContactLian Cuihong
Shenzhen Second People's Hospital
Outcome results
None listed