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Treatment of Skin Expansion with autologous concentrate growth factor combined with basic fibroblast growth factor (bFGF): a single-arm clinical trial

Treatment of Skin Expansion with autologous concentrate growth factor combined with basic fibroblast growth factor (bFGF)

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100047757
Enrollment
Unknown
Registered
2021-06-26
Start date
2019-01-01
Completion date
Unknown
Last updated
2022-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

skin defect

Interventions

CGF+bFGF:Intradermal injection with CGF combined bFGF

Sponsors

Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Eligible participants met the following inclusion criteria: 14 to 65 years old without a gender preference; an indication of deterioration in expanded skin texture, such as thin/papery skin, angiotelectasia, and dermis striatum that showed no improvement after suspending expansion for 2 weeks; and a requirement for further expansion to achieve reconstruction. All patients were assessed by two independent plastic surgeons for eligibility.

Exclusion criteria

Exclusion criteria: (1) Presence of infection in the expansion area; (2) presence of expanded skin in a haired area; (3) a history of severe illnesses, such as diabetes, hepatitis, coronary heart disease, arteriosclerosis, glomerulonephritis, blood system diseases, autoimmune diseases, etc.; and (4) current smoking or smoking cessation for less than 6 months before enrollment.

Design outcomes

Primary

MeasureTime frame
skin thickness;

Secondary

MeasureTime frame
Expansion index;Expanded skin surface area;

Countries

China

Contacts

Public ContactLiu Kai

Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine

drkailiu@126.com+86 13482514585

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026