Comparing butorphanol with sufentanil in patients ongoing mechanical ventilation: a single center, randomized controlled, non-inferiority study

Analgesic effect of butorphanol versus sufentanil on patients with mechanical ventilation

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100047754

Enrollment

Unknown

Registered

2021-06-26

Start date

2021-09-01

Completion date

Unknown

Last updated

2022-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

analgesia

Interventions

Experimental group:Butorphanol intravenous injection

Control group:Sufentanil intravenous injection

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged 18 years or older; 2. Expected ventilation for more than 24 h; 3. Ventilation for less than 48 h at the time of enrolment; 4. Need sedation and analgesia treatment; 5. Written informed consent.

Exclusion criteria

Exclusion criteria: 1.Allergy to any of the study medications; 2.Alcoholism; 3.Pregnancy; 4.Expected Major surgery within 3 days of enrolment; 5.World Health Organization chronic pain grade 3 or above; 6.Regular use of potent opioids such as morphine; 7.Recent opioid analgesia via a spinal catheter, epidural or any other regional technique; 8.American Society of Anesthesiologists (ASA) classification 5 patients (moribund); 9.Neurotrauma or organic brain pathology.

Design outcomes

Primary

Measure	Time frame
Mechanical ventilation time;pain rating scale;	—

Countries

China

Contacts

Public ContactWang Zhen

Department of Critical Care Medicine, Wannan Medical College First Affliated Hospital, Yijishan Hospital

zhenwang80@126.com+86 13365713523

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026