postoperative analgesia
Conditions
Interventions
Experimental Group:nalmefene 0.2 µg/kg
Control Group:normal saline 0.2 µg/kg
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients receiving laparoscopic gastrointestinal surgery ; 2. American Society of Anesthesiologists physical status is I-III; 3. Aged 18 to 75 years.
Exclusion criteria
Exclusion criteria: 1. Subject is allergic to nalmefenesubject has pregnancy; 2. Subject has a diagnosis of severe cardiac, neurological and vascular diseases; 3. Subject has a diagnosis of severe high blood pressure(preoperative systolic BP >= 180mmHg or preoperative diastolic BP >= 110mmHg ); 4. Subject with severe impairment of hepatic and renal function, gastrointestinal bleeding ulcer, ischemic peripheral vascular disease, aspirin asthma or hematologic disorder ; 5. Subject has severe opioids dependence ; 6. Subject can not complete the subjective assessment scale due to mental disorders and other reasons; 7. Subject with BMI >=30kg/m2; 8. Subject with BMI<18kg/m2; 9. Subject refuses to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of major side effects of opioid analgesia;opioid consumption; | — |
Secondary
| Measure | Time frame |
|---|---|
| pain;influence of pain on sleep mood;abdominal distention;Oxygen saturation;Respiratory rate;postoperative analgesia pump drug consumption;rescue analgesics;Time of first ambulation after operation;first feeding;time of detubation of stomach tube;Discharge time; | — |
Countries
China
Contacts
Public ContactMi Weidong
Chinese PLA General Hospital
Outcome results
None listed