Traumatic Brain Injury
Conditions
Interventions
Treatment group:Sequential hydrogen inhalation and hyperbaric oxygen therapy on the basis of conventional treatment and nursing
Control group:Hyperbaric oxygen therapy on the basis of conventional treatment and nursing
Sponsors
The Sixth Medical Center of PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Subjects aged 18 to 65 years, at the time of signing the informed consent; 2.Subjects who have suffered from moderate to severe traumatic brain injury combined with obvious contusion and laceration in CT imaging; 3.Within 72 hours after injury.
Exclusion criteria
Exclusion criteria: 1.Operation was performed 48 hours after injury; 2.Respiratory failure caused by severe lung disease; 3.Have a history of serious dysfunction of other organs outside the brain, such as heart, liver, kidney, coagulation dysfunction, etc; 4.Severe brain stem injury, simple epidural hematoma, intracranial infection; 5.History of neurological and psychiatric diseases affecting neurological function scores; 6.Participation in another experimental trial with active interventions; 7.Pregnant or lactating patients; 8.The researchers believe that others are not suitable to participate in clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glasgow coma scale;extended Glasgow Outcome Scale score;Barthel index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain functional magnetic resonance;Electroencephalogram;Cerebrospinal fluid test;Blood test; | — |
Countries
China
Contacts
Public ContactGuo Dazhi
The Sixth Medical Center of PLA General Hospital
Outcome results
None listed