Diffuse Large B-cell Lymphoma
Conditions
Interventions
Experimental group:ZR2 miniCHOP regimen
Sponsors
The First Affiliated Hospital of Zhejiang University Medical College
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. According to the histopathological diagnosis of newly diagnosed DLBCL patients, immunohistochemical results showed that CD20 was positive; 2. Non-GCB DLBCL according to Hans classification; 3. There is at least one imaging measurable lesion; 4. Aged 60 to 80 years old and ECOG score >= 2, or age >= 80 years old and ECOG score 0-4; 5. Obtain the informed consent signed by the patient or his family.
Exclusion criteria
Exclusion criteria: 1. Pregnant, lactating women and women of childbearing age who are unwilling to take contraceptive measures; 2. Abnormal liver function (total bilirubin > 1.5 times of the upper limit of normal, ALT / AST > 2.5 times of the upper limit of normal or ALT / AST > 5 times of the upper limit of normal) and abnormal renal function (serum creatinine > 1.5 times of the upper limit of normal); 3. Except for lymphoma, absolute neutrophil count 1x10^3 copy number /ml), untreated syphilis positive and active TB patients; 9. History of lymphoma and Richter's syndrome; 10. Other researchers judged that they were not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall response rate; | — |
Countries
China
Contacts
Public ContactJin Jie
The First Affiliated Hospital, Zhejiang University College of Medicine
Outcome results
None listed