Mitochondrial dysfunction during aging
Conditions
Interventions
Experimental group:Yuanheng Solid Drink, 2 bags per use, once daily, dissolved with warm water, treat for 16 weeks (equal to 112 days)
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Male
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 45 to 60 years, healthy pre-senile men; 2. 18.5<= BMI<30; 3. Able to act independently; 4. Non-heavy manual workers; 5. There is no large amount of exercise during the test; 6. No longer participate in clinical trials of any other research center during the trial; 7. Voluntarily sign the informed consent; 8. After the primary screening of the PPSHAS scale, the grades iii and iv of aging are selected. If the number of cases of grade IV can meet the target of 40 cases, the grade IV is preferred.
Exclusion criteria
Exclusion criteria: 1. There is a malabsorption syndrome that may affect the absorption of the test substance; 2. Those who work night shifts or alternate between day shifts and night shifts; 3. Allergic to herbal supplements; 4. Those who have used anti-aging products within 1 month before the start of the trial; 5. Dyslexia; 6. Currently have the habit of smoking; 7. Drinking alcohol more than 14 times a week; 8. Any situation that the researcher considers inappropriate to participate in this research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphological observation of mitochondria in peripheral blood immunocytes;Copy number of mtDNA in peripheral blood immunocytes;Mitochondrial membrane potential of peripheral blood mononuclear cells;coenzyme i level in serum;Sirt1 level in serum;8-oxodG level in serum; | — |
Secondary
| Measure | Time frame |
|---|---|
| Decreasing rate of Malondialdehyde level in serum;Upgrade rate of Superoxide Dismutase in serum;advanced glycation end products level in serum; | — |
Countries
China
Contacts
Public ContactZheng Yuxin
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed