A prospective study on the clinical characteristics of neonatal hyperbilirubinemia caused by congenital liver disease

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100047697

Enrollment

Unknown

Registered

2021-06-22

Start date

2021-06-22

Completion date

Unknown

Last updated

2022-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

congenital liver disease

Interventions

Case series:No

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Neonatal hyperbilirubinemia; 2. Diagnosed hepatolenticular degeneration,Gilbert syndrome,Crigler-Najjar syndrome,Dubin-Johnson syndrome and familial intrahepatic cholestasis.

Exclusion criteria

Exclusion criteria: 1. Congenital biliary atresia; 2. Congenital bile duct cyst; 3. Neonatal sepsis; 4. Intravenous nutrition for more than 2 weeks; 5. Failure of various organs; 6. Shock; 7. Parents do not agree to improve family genetic testing or follow-up.

Design outcomes

Primary

Measure	Time frame
serum total bilirubin;serum direct bilirubin;glutamic-pyruvic transaminase;liver ultrasound;Metabolic Blood Screening;Metabolic Blood Screening;Next generation sequencing;development assessment;	—

Countries

China

Contacts

Public ContactWang Feng

Neonatal intensive care unit of department of Pediatrics, Seventh Medical Center, PLA General Hospital

wf_316@sina.com+86 18600317210

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026