Preventing pain on injection of propofol: a comparison between nalbuphine pre-treatment and nalbuphine added to propofol

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100047682

Enrollment

Unknown

Registered

2021-06-21

Start date

2021-07-01

Completion date

Unknown

Last updated

2022-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Propofol injection pain

Interventions

control group:Normal saline

Pre-administration group:Nalbuphine pre-treatment

Mixed administration group:nalbuphine added to propofol

Eligibility

Sex/Gender

Female

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Female; 2. ASA grade I-II; 3. 18-55 years old; 4. Patients who will perform elective gynecological hysteroscopy under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Preoperative history of oral opioids; 2. Patients with severe liver and kidney insufficiency, cardiovascular or nervous system diseases or thrombophlebitis; 3. Allergic to the study drug; 4. Patients with serious mental illness or language communication difficulties; 5. Patients with difficult airway and obesity (BMI >=30 kg/m2); 6. For other reasons, they were not considered suitable subjects for study.

Design outcomes

Primary

Measure	Time frame
The incidence of injection pain;	—

Secondary

Measure	Time frame
Severity of the injection pain;Patients' satisfaction degree;Total amount of propofol;	—

Countries

China

Contacts

Public ContactZeng Jianfeng

Sun Yat-sen Memorial Hospital of Sun Yat-sen University

mzkzjf@hotmail.com+86 18676638804

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026