The effect of preoperation L-dopa therapy on subthalamic deep brain stimulation

The effect of preoperation L-dopa therapy on intraoperative microelectrode recording and clinical outcome for subthalamic deep brain stimulation under local anesthesia

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100047674

Enrollment

Unknown

Registered

2021-06-21

Start date

2021-07-01

Completion date

Unknown

Last updated

2022-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

parkinson‘s disease

Interventions

“on-medication” group:preoperation L-dopa therapy

“off-medication” group:discontinue L-dopa the night before surgery

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Compliance with the diagnostic criteria of primary PD; 2. Treated with bilateral STN DBS; 3. Experienced a decrease in antiparkinson medication efficacy or drugs-induced serious side effect; 4. An improvement rate of at least 30% in the L-dopa challenge test according to UPDRS motor score.

Exclusion criteria

Exclusion criteria: 1. Severe cognitive impairment, anxiety, depression which has impact on patients daily living ability; 2. Parkinsonism-plus syndrome or various forms of secondary Parkinson syndromes; 3. Obvious medical comorbidities that affected surgery or survival, or other chronic diseases with an expected survival rate of less than one year.

Design outcomes

Primary

Measure	Time frame
The length of MER recording;Clinical outcome;	—

Countries

China

Contacts

Public ContactZhang Jie

Zhongnan Hospital of Wuhan University

zhangstereo123@126.com+86 13317196255

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026