elderly patients with Alzheimer's disease
Conditions
Interventions
Gold Standard:neuropsychological scale
kit 
to 
jointly 
the 
AD7C-NTP, 
blood 
P-TAU-181 
and 
Aß1-42
Sponsors
Drum Tower Hospital of Nanjing Medical University
Eligibility
Sex/Gender
Male
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Elderly aged 60-85; 2. Well cooperated to complete the neuropsychological scale test, urine test, blood test; 3. Sign informed consent; 4. The subjects will be divided into NC group, SCD group and MCI group for the first time according to the score of neuropsychological scale. (1) Diagnostic criteria of SCD: 1) Compared with the previous normal state, self-perceived persistent cognitive decline which is not related to acute events; 2) All the standard cognitive tests adjusted for age, sex and education level were normal; 3) In addition, SCD that may be preclinical for AD also has the following characteristics : subjective memory but not other cognitive domains decline; within 5 years of onset; age of onset >=60 years old; SCD-related concerns (or concerns); feeling worse than the same age group; the diagnosis is more likely to be confirmed by people with knowledge, ApoE e4 genotype and other biomarkers of AD; (2) MCI diagnostic criteria: 1) The chief complaint of subjective memory decline has been confirmed by their family members or escorts; 2) There was MCI evidence after objective Examination. 3) Clinical Dementia Rating (CDR) of one or more neighborhoods >=0.5 points; Total CDR 24 points.
Exclusion criteria
Exclusion criteria: 1. Clinical stroke or history of stroke: Head MRI showed lesions with a diameter of > 2cm (if there was imaging evidence of subcortical, periventricular and deep cerebral infarction, except those with five symptoms and corresponding history); 2. The Hachinski Ischemia Index Scale> 4; 3. Cognitive impairment caused by intracranial space-occupying lesions, central nervous system infection, craniocerebral injury, epilepsy, multiple sclerosis, toxic metabolic disease, Parkinson's disease, intracranial tumor, hypothyroidism, etc; 4. Depression or anxiety, schizophrenia; Have a history of alcohol or drug dependence; Taking cognitive-improving medications; 5. Complicated with serious heart, liver and kidney dysfunction and urinary system diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SEN, SPE, ACC, AUC of ROC;SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactLi Shanshan
Nanjing Drum Tower Hospital
Outcome results
None listed